As a follow up project to the MTASC, the Motion-Twin ActionScript Compiler, Nick Cannasse has been working on haXe, a language that can be compiled to Flash, DHTML, or mod_neko, a VM embedded in an Apache plugin.
The mind boggles. A high-level JavaScript like language that compiles to virtual machines embedded in within a browser or webserver. What? No Java virtual machine? Given haXe's heritage, it can't be that hard to implement translation of a simplified version of Python in a similar fashion. Don't know if it would be worth the trouble though.